I read this and googled "A Tangled Skein" (I'm bored as hell) and I got this from The Other Wiki's article on a book called "With A Tangled Skein." (Sorry for the wall of text.)
"The Tapestry of life is an immeasurably enormous tapestry, containing all the threads of life from the beginning of time to the end, chronicling all of human existence. Fate's task is to build and maintain the tapestry, though like all of the Incarnations, she has a staff that handles the routine issues - there is simply too much for her to do it all herself. The Tapestry has many unusual properties - its main one being that it does not function as something only half complete. It does not end where they are working on it, but simply fades into the future, or becomes impenetrably tangled and impossible to read. Correcting these tangles is what takes up much of Fate's time, in addition to working with Chronos to schedule where in the tapestry each thread should be anchored and where it should be cut. A semi-physical form of the Tapestry resides in Fate's Abode, but it is merely a representation - the true Tapestry is so massive and complex as to be incomprehensible except at a very specific level. As such, the Tapestry can only be harmed indirectly, by altering individual events - the Tapestry as a whole remains largely untouchable."
Might be nothing but he could be telling us to focus on the individuals, like Poirot or the patient, rather than looking at the wall.
Marching on together.